Brugada syndrome is a disorder characterized by sudden death associated with one of several ECG patterns characterized by incomplete right bundle branch block and ST elevations in the anterior precordial leads. (See Media File 2). In the initial description of Brugada syndrome, the heart was reported to be structurally normal, but this has recently been challenged.1 Moreover, subtle structural abnormalities in the right ventricular outflow tract can also be observed. The typical patient with Brugada syndrome is young, male, and otherwise healthy, with normal general medical and cardiovascular physical examinations.
Patients with Brugada syndrome are prone to develop ventricular tachyarrhythmias that may lead to syncope, cardiac arrest, or sudden cardiac death.2,3,4 Infrahisian conduction delay and atrial fibrillation may also be manifestations of the syndrome.5,6 Brugada syndrome is genetically determined and has an autosomal dominant pattern of transmission in about 50% of familial cases. About 5% of survivors of cardiac arrest have no clinically identified cardiac abnormality; about half of these cases are thought to be due to Brugada syndrome.7
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